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dimethylamino group significantly enhances the MOR affinity, as in U-47700. In contrast, embedding that same fundamental nitrogen into a cyclic pyrrolidine ring significantly boosts the KOR affinity, as in U-50488. MOR/KOR selectivity is affected through the NSince FUBIMINA wasn't active at doses up to one hundred mg/kg i.p., a probe dose of 56 mg/

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